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Illuminating Disease: An Introduction to Green Fluorescent Proteins, by Marc Zimmer
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Green fluorescent proteins have been floating in the ocean for more than 160 million years, but it took a curious scientist, fascinated by pinpricks of green light, to begin unlocking their potential. Now these jellyfish proteins have become one of the most important tools available to researchers in modern medicine and biology. By using them to illuminate other proteins that were previously invisible even under a microscope, scientists are now able to observe facets of disease that would have otherwise gone undetected. Green fluorescent proteins are used in over three million experiments a year and have proved invaluable for tasks such as tracking HIV, breeding bird flu-resistant chickens, and confirming the existence of cancerous stem cells.
In Illuminating Disease, Marc Zimmer introduces us to these revolutionary proteins, acquainting readers both with the researchers responsible for the proteins' discovery as well as their wide utility. The book details the history of genetically modified fluorescent parasites and viruses, which provide scientists with lifesaving information about the spread of diseases. Green fluorescent proteins allow scientists and doctors to understand diseases better by quite literally illuminating various microscopic interactions occurring in living cells that otherwise would have gone unseen.
The book is richly illustrated, showing the visually striking uses of green fluorescent proteins, and many of these scans have won awards in biological imaging competitions. An ideal introduction for students and advanced researchers alike, Illuminating Disease is an accessible yet deeply probing investigation into one of the most important developments in medical research of the last several decades.
- Sales Rank: #1114153 in Books
- Published on: 2015-01-13
- Original language: English
- Number of items: 1
- Dimensions: 6.40" h x .90" w x 9.40" l, 1.35 pounds
- Binding: Hardcover
- 240 pages
Review
"When the Nobel Prize in chemistry was awarded for the discovery of green fluorescent protein (GFP) in 2008, the Nobel Committee called GFP a guiding star for biochemistry enabling processes that were previously invisible, such as cancer cells spreading, to be strikingly visible. Marc Zimmer, has written a "glowing account" of how GFP and its red, blue, yellow and orange cousins have revolutionized bio-medical research and enabled every major disease, both cause and effect, to "light-up" in the laboratory for researchers to visualize, understand and eventually conquer them. This exciting and landmark book on the wonderful story of GFP is written with great clarity, warmth and for everyone." --Dr. Robert M. Hoffman, President, Anticancer, Inc.
"I am tempted to say that this book is to GFP what "the double helix" is to DNA. Zimmer's pleasant and captivating account features a whole range of scientific problems, framed with personal stories and anecdotes. Zimmer manages to tell stories across many fields of disease (cancer, heart, brain, infections) that are not usually put together into one volume and thus provides a rare unifying read across biology. The nicely illustrated book clearly is a must-read for all students of biology." --Friedrich Frischnecht, Department of Parasitology, University of Heidelberg Medical School
"For many years, GFP attracted keen attention of scientists because of its unique biochemistry and practical usefulness, and simply due to its aesthetic beauty. Dr. Zimmer describes a lot of facts of medicine and basic biology, but at the same time does not forget to explain all basics to non-scientist readers, often suggesting surprising and illustrative parallels with everyday life. The book is full of stories of people who made key discoveries and technical breakthroughs in the field, and it shows an exciting flow of appearance and implementation of scientific ideas." --Sergey Lukyanov, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry
"'Illuminating Disease' achieves a difficult synthesis between discussing various diseases that are rarely mentioned within a single book and the molecular biology of fluorescent proteins without losing accessibility for a generalist reader. It is this mix that makes 'Illuminating Disease' stand out. Zimmer's account will provide students with an access point to the history and application of fluorescent proteins. There really is something for everyone here: from the interested lay-scientist through to the undergraduate student to those researchers that take GFP for granted in their daily research. And it is with this appreciation that the current book will serve the scientific community well." --Bioessays
"The book is well written, and the discussion is sufficiently detailed to be useful but not so complex as to overwhelm readers with minutiae. This is an informative read for those in the health science disciplines. Highly recommended." --Choice
About the Author
Marc Zimmer is Professor of Chemistry at Connecticut College. He has published articles on science and medicine for the Los Angeles Times, USA Today, and the Huffington Post, among many other publications.
Most helpful customer reviews
1 of 1 people found the following review helpful.
Zimmer Shines a Biofluorescent Flashlight On Things You Never Could Have Imagined.
By En-light-ened Reader
This is a book for the scientist and the layman alike! As a premedical college student who actually has next to zero scientific background, this was truly an intriguing read. Zimmer bridges audiences of the humanities and the sciences. His writing is clever, dry and humorously understated. His narratives capture attention with romantic images of foreign intrigue and action, and captivate a wide audience with the dubious juxtaposition of international enterprise and the misunderstood world of science. This reader can guarantee you will never look at the exciting fields of medicine and genetic engineering the same way again- or for that matter, global disease and epidemic.
You'll gain new insight into under-prioritized and neglected diseases, from Malaria to Chagas, that afflict hundreds of millions every year, as well as the social, ethical and geo-political issues that surround each disease. Perhaps you may acquire an appreciation for the privilege in your own life- maybe you'll be galvanized by this impetus to help the rest of the world. You'll learn the fascinating history of each disease, from the plights of ancient times to the tribulations of those individuals who have originated our current methods of retaliation. And, of course, you'll discover how scientists at the very forefront of technology have harnessed the power of the light-emitting tools nature itself has provided them to combat the greatest plagues of its own creation.
You may be horrified by the torment of millions, but stimulated by the proverbial "light at the end of the tunnel" that proteins like GFP offer. Great! Become inspired by what nature and science have to offer us, in application to our own lives. Be dazzled, be beguiled, be amazed with what Zimmer has to offer in Illuminating Disease: because chances are, it's something you've never heard of before. Become enlightened, as yours truly has. ~WD
1 of 1 people found the following review helpful.
A Great Read for Everyone
By Brian Bahena
Marc Zimmer has successfully written a book aimed to both the scientific and casual reader. A straightforward GFP guide, which begins with the story of Osamu Shimomura, a scientist from Japan who was one of the first to research and attempt to understand GFP, and continues through current scientists and their research using GFP. The reader is kept hooked by the storytelling that follows along with the science behind GFP and the diseases discussed in the book. Do not be fooled by the title and think you will only read detailed science material about certain diseases and GFP. This book will also provide you with history/short biographies of the scientists who used GFP to better understand diseases. Zimmer writes with much simplicity and clarity. Even with its simple language no detail is left out. The introduction itself lays down a detailed history of the GFP that provides necessary context to understand the complexity and importance of GFP.
"Illuminating Disease: An introduction to Green Fluorescent Proteins" is just that an intro meant to inform readers of the great tool that GFP is while passing along Zimmer's enthusiasm and love for the subject matter in a short 240 pages of text. A great read for the high school student with a passion for science, for the college student pursuing a science degree, or for the casual reader just looking for a fun read and wanting to learn something new.
~BB
1 of 1 people found the following review helpful.
Glowing Reviews
By All systems glow
This book is very interesting and engaging. It gives new perspective on diseases and gives nice background and information on the research of diseases that takes place. Filled with funny little quips it remains humorous but informative. Zimmer narrates it in a very story-like way at some points, humanizing the scientists and giving insight on the actual process they experienced. It is definitely worth a read!
~MG
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